This brief article presents the introduction and draft of the fundamental ideas developed at length in the book of the same title, which gives a challenging point of view about science and its history/philosophy/sociology. Science is in decline. After centuries of great achievements, the exhaustion of new forms and fatigue have reached our culture in all of its manifestations including the pure sciences. Our society is saturated with knowledge which does not offer people any sense in their lives. There is a loss of ideals in the search for great truths and a shift towards an anodyne specialized industry.